Our technology and expertise to simplify complex chemistries


4 R&D facilities with a combined 45000 Sq. ft built up area. Highly skilled and diverse team comprising of PhD’s, post graduates and chemical engineers


Expertise in handling multi-step complex chemistry, extended  coupling reactions, nucleoside &  carbohydrate chemistry, asymmetric catalysis,  hydrogenation, organometallics and chiral products including the development of suitable analytical chiral methods


Capability to handle and develop cytotoxic intermediates/API


Capability to carry out full-scale patent evaluation including development of non-infringing processes & collaborative programs under confidentiality agreement


State-of-the art Analytical labs with NMR, ICP – OES HPLC, UPLC, GC, GC-HS, GC-MS/MS, LCMS along with stability & photo stability chambers


Capability for evaluation & development including validation of analytical test methods for Genotoxic and Nitrosamine impurities

R&D Core Competence

Carbonylations using carbon monoxide on multi kilo scale

Palladium Foray  into Coupling  Reactions for C-C  and C-N bond  formations

Capability to handle high potency molecules

LaCl3/LiCl catalysed Alkyl Grignard reactions

Cryogenic (up to-90°C), organometallic, pyrophoric reagents and reactions

  • Suzuki Coupling using Miyaura borylated species
  • Negishi Coupling with alkyl zinc bromides 
  • Stille: Between organohalides & organotin compounds
  • Buchwald Hartwig: Between aryl halide & amine  or aryl alcohol
  • Tsuji-Trost: Between alkene and a nucleophile  
  • Heck- Matsuda: Between alkenes and alkyl halides 
  • Expertise in selection of Palladium catalyst & ligands such as
    • Pd(OAc)2, Pd2(dba)3.DCM, Pd(PPh3)4, Pd(PPh3)2Cl2
    • RuPhos, SPhos, X-Phos and xantphos
  • Asymmetric C – C & C – N bond formation 
  • Asymmetric transformation
  • Reductive Amination
  • Chiral separations
  • Gilman reaction on production scale
  • Solid distillation (Upto 0.01 torr)
  • Phase Transfer Catalysis
  • Copper catalyzed Ullmann Reaction

Pathbreaking chemistry innovation in Camptothecin derivatives

Natural Route

Synthetic Approach

  • Camptothecin is a natural alkaloid isolated from bark and stem of Camptotheca acuminate and is used for the synthesis of cytotoxic molecules like  SN-38, Irinotecan etc. Irinotecan is one of the widely used chemotherapy drugs
  • Use of Camptothecin from natural source has its limitation with respect to availability and quality resulting from presence of related natural  products as impurities
  • Cohance is the global pioneer in developing a fully synthetic route for the large scale production of Camptothecin derivative SN-38. Our proprietary technology allows us to produce SN-38 & Irinotecan with significantly higher level of purity as compared to the same from semi synthetic pathway
  • We have leveraged this technology to synthesize payloads for ADCs (Antibody drug conjugates). We are supporting several innovators in their ADC clinical programs

Expertise in building complex structural blocks